Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018

David W. Eyre*, Nicholas D. Sanderson, Emily Lord, Natasha Regisford-Reimmer, Kevin Chau, Leanne Barker, Markus Morgan, Robert Newnham, Daniel Golparian, Magnus Unemo, Derrick W. Crook, Tim E.A. Peto, Gwenda Hughes, Michelle Cole, Helen Fifer, Anne Edwards, Monique I. Andersson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

139 Citations (Scopus)

Abstract

We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.

Original languageEnglish
Article number1800323
JournalEurosurveillance
Volume23
Issue number27
DOIs
Publication statusPublished - 5 Jul 2018

Bibliographical note

Funding Information:
The research was supported by the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Healthcare Associated Infections and Antimicrobial Resistance at the University of Oxford in partnership with Public Health England (PHE); and by the NIHR Biomedical Research Centre Oxford. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, the Department of Health or Public Health England. NIHR HPRU Independent Steering Committee: John Coia, Neil French, Charis Marwick, Mike Sharland. DWE is a NIHR Clinical Lecturer and Robertson Foundation Fellow. TEAP and DWC are NIHR Senior Investigators.

Publisher Copyright:
© 2018, European Centre for Disease Prevention and Control (ECDC). All rights reserved.

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