Hematopoietic stem and progenitor cell responses to low radiation doses–implications for leukemia risk

Nathalie Gault, Tom Verbiest, Christophe Badie, Paul Henri Romeo, Simon Bouffler*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Studies of the responses of hematopoietic stem and progenitor cells (HSPCs) to low doses of ionizing radiation formed an important aspect of the RISK-IR project (www.risk-ir.eu). A brief overview of these studies is presented here. The findings confirm the sensitivity of HSPCs to radiation even at low doses, and illustrate the substantial impact that differentiation state has upon cell sensitivity. The work provides mechanistic support for epidemiological findings of leukemia risk at dose levels used in diagnostic CT imaging, and further suggests that low-dose irradiation may facilitate bone marrow transplantation, a finding that could lead to refinements in clinical practice.

Original languageEnglish
Pages (from-to)892-899
Number of pages8
JournalInternational Journal of Radiation Biology
Volume95
Issue number7
DOIs
Publication statusPublished - 3 Jul 2019

Bibliographical note

Funding Information:
The authors received funding from the European Union Euratom Seventh Framework Programme RISK-IR project under grant agreement 323267.

Publisher Copyright:
© 2019, Copyright © 2019 Taylor & Francis Group LLC.

Keywords

  • Radiation
  • hematopoiesis
  • leukemia
  • stem cells

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