Hyporesponsiveness and its clinical implications after vaccination with polysaccharide or glycoconjugate vaccines

Jan Poolman, Raymond Borrow

    Research output: Contribution to journalReview articlepeer-review

    104 Citations (Scopus)

    Abstract

    Hyporesponsiveness (immune tolerance) follows vaccination with meningococcal polysaccharide and many pneumococcal polysaccharide serotypes. Hyporesponsiveness after Haemophilus influenzae type b polysaccharide vaccination has not been directly observed, but may follow exposure during disease in some individuals. Use of currently licensed conjugate vaccines has not been associated with hyporesponsiveness to date, with the possible exception of pneumococcal serotype 3. Introduction of polysaccharide vaccines anywhere into a conjugate vaccination schedule may result in reduced immune responses on subsequent exposure. This review of vaccine-induced hyporesponsiveness and its potential clinical implications considers recent evidence suggesting that hyporesponsiveness may occur for specific components of combined conjugate vaccines, such as pneumococcal serotype 3. These data have implications for the development of new multivalent vaccines.

    Original languageEnglish
    Pages (from-to)307-322
    Number of pages16
    JournalExpert Review of Vaccines
    Volume10
    Issue number3
    DOIs
    Publication statusPublished - Mar 2011

    Keywords

    • conjugate vaccines
    • hyporesponsiveness
    • immune tolerance
    • vaccination

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