Members of the family Filoviridae produce variously shaped, often filamentous, enveloped virions containing linear non-segmented, negative-sense RNA genomes of 15–19 kb. Several filoviruses (e.g., Ebola virus) are pathogenic for humans and are highly virulent. Several filoviruses infect bats (e.g., Marburg virus), whereas the hosts of most other filoviruses are unknown. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on Filoviridae, which is available at www.ictv.global/report/filoviridae.
Bibliographical noteFunding Information:
Production of this summary, the online chapter and associated resources was funded by a grant from the Wellcome Trust (WT108418AIA). This work was supported in part through Battelle Memorial Institute’s prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I (J.H.K.). This project was funded in part with federal funds from the National Cancer Institute, National Institutes of Health under Contract No. HHSN261200800001E. This work was also funded in part under Contract No. HSHQDC-15-C-00064 awarded by Department of Homeland Security (DHS S&T) for the management and operation of the National Biodefense Analysis and Countermeasures Center (NBACC), a federally funded research and development center (V.W.). The views and conclusions contained in this document are those of the authors and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the US Department of the Army, the US Department of Defense, the US Department of Health and Human Services, or of the institutions and companies affiliated with the authors. In no event shall any of these entities have any responsibility or liability for any use, misuse, inability to use or reliance upon the information contained herein. The US departments do not endorse any products or commercial services mentioned in this publication.
Received 7 March 2019; Accepted 8 March 2019; Published 25 April 2019 Author affiliations: 1NIH/NIAID Integrated Research Facility at Fort Detrick, (IRF-Frederick), Frederick, MD 21702, USA; 2Washington University School of Medicine, St. Louis, MO 63110, USA; 3Center for Microbial Pathogenesis, Georgia State University, Atlanta GA 30303, USA; 4United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA; 5The University of Texas Medical Branch, Galveston, TX 77555, USA; 6Albert Einstein College of Medicine, Bronx, NY 10461, USA; 7Integrated Research Facility at Fort Detrick, Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research supported by the National Cancer Institute, Frederick, MD 21702, USA; 8Institute of Virology, Philipps University Marburg, 35043 Marburg, Germany; 9World Health Organization, CH-1211 Geneva, Switzerland; 10Department of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA 02118, USA; 11Public Health England, Porton Down, Wiltshire, SP4 0JG Salisbury, UK; 12Université Laval, Québec City, QC G1V 0A6, Canada; 13Infectious Diseases and Vectors Unit, Institut de Recherche pour le Développement, 911 Av Agropolis, 34394 Montpellier, France; 14Novosibirsk State University, Novosibirsk, Novosibirsk Oblast, 630090, Russia; 15National Biosafety Laboratory, National Public Health Center, Budapest, Hungary; 16National Institute for Communicable Diseases of the National Health Laboratory Service, 2131 Sandringham-Johannesburg, Gauteng, South Africa; 17Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK; 18Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, 001-0020 Sapporo, Japan; 19Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; 20National Biodefense Analysis and Countermeasures Center, Frederick, MD 21702, USA. *Correspondence: Jens H. Kuhn, firstname.lastname@example.org Keywords: Filoviridae; filovirus; ICTV Report; ebolavirus; marburgvirus; taxonomy. Abbreviations: L, RNA-dependent RNA polymerase; NP, nucleoprotein; RNP, ribonucleoprotein.
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