Immune response of premature infants to meningococcal serogroup C and combined diphtheria-tetanus toxoids-acellular pertussis-Haemophilus influenzae type b conjugate vaccines

Martin H. Slack, David Schapira, Richard J. Thwaites, Moya Burrage, Joanna Southern, Nicholas Andrews, Raymond Borrow, David Goldblatt, Elizabeth Miller

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    Abstract

    To determine the immune response of premature infants to meningococcal serogroup C capsular polysaccharide (MCC) and combined diphtheria-tetanus toxoids-acellular pertussis-Haemophilus influenzae type b (DTaP-Hib) conjugate vaccines, 105 infants born at < 32 weeks' gestation had Hib IgG geometric mean concentrations (GMCs) and MCC serum bactericidal antibody (SBA) geometric mean titers (GMTs) measured 1 month after the third immunization. Term infants served as control subjects. Premature infants had Hib GMCs of 0.27 μg/mL, with 21% achieving GMCs > 1.0 μg/mL, compared with 0.81 μg/mL and 46% in term infants (P < .001 and P = .003, respectively). The MCC SBA GMT was 398, with 99% achieving an SBA ≥8, compared with 380 and 98% in term infants (P = .84 and P = 1.0, respectively). Hib IgG was associated with age at third immunization (P < .001). When combined with the DTaP vaccine used in this study, the Hib GMC of premature infants was extremely low. The SBA GMT to MCC was similar to that of term infants.

    Original languageEnglish
    Pages (from-to)1617-1620
    Number of pages4
    JournalJournal of Infectious Diseases
    Volume184
    Issue number12
    DOIs
    Publication statusPublished - 15 Dec 2001

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