In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci

David Livermore, Marina Warner, Shazad Mushtaq, Sarah North, Neil Woodford

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

RWJ-416457, a novel oxazolidinone, had modal MICs of 0.5 to 1 μg/ml for linezolid-susceptible staphylococci and enterococci, versus linezolid MICs for these organisms of 1 or 2 μg/ml. RWJ-416457 MICs for mutants with 23S rRNA mutations were 2 to 32 μg/ml, versus linezolid MICs of 8 to 64 μg/ml; actual values reflected the proportion of gene copies mutated.

Original languageEnglish
Pages (from-to)1112-1114
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number3
DOIs
Publication statusPublished - Mar 2007

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