In vitro evaluation of the antibiofilm properties of chlorhexidine and delmopinol on dental implant surfaces

Derren Ready*, Georgios Theodoridis, Ingrid Green, Lena Ciric, Jonathan Pratten, Weiming Tay, Ailbhe McDonald

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Biofilm development on the internal surfaces of dental implants and dental implant components may be associated with peri-implant hard and soft tissue abnormalities. Currently, no protocols have been established for effective disinfection of removable implant components. The purpose of this study was to evaluate the antibiofilm properties of commonly used dental antimicrobial agents (chlorhexidine and delmopinol) on multispecies biofilms. Biofilms of 48 h and 168 h maturity were exposed to 0.2% chlorhexidine, 2% chlorhexidine and a product containing 0.2% delmopinol for 5, 10 and 20 min. 2% chlorhexidine was the most effective agent, achieving a total viable biofilm reduction ranging from 96.2% to >99.99% depending on the time of exposure and the stage of biofilm development.

Original languageEnglish
Pages (from-to)662-666
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume45
Issue number6
DOIs
Publication statusPublished - 16 May 2015

Bibliographical note

Funding Information:
Funding : This work was undertaken at the University College London Hospitals/University College London, which received a proportion of funding from the UK Department of Health's National Institute for Health Research Biomedical Research Centres funding scheme.

Keywords

  • Antimicrobial susceptibility
  • Biofilm
  • Dental implant components
  • Disinfection

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