In-vitro photobactericidal activity of aminoacridines

M. Wainwright*, D. A. Phoenix, J. Marland, D. R.A. Wareing, F. J. Bolton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

The toxicities of several aminoacridines were measured against pathogenic strains of both Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) organisms. In several cases, illumination at a light dose of 6.3 J/cm2 resulted in considerable decreases in the minimum lethal drug concentrations required, giving up to 50-fold increases in bactericidal activity. Derivatives of 9-aminoacridine (aminacrine) exhibited phototoxicity against one or more of the test organisms, but the established photosensitizing acridines proflavine and acridine orange were photobactericidal against all strains.

Original languageEnglish
Pages (from-to)587-589
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Volume40
Issue number4
DOIs
Publication statusPublished - Oct 1997
Externally publishedYes

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