The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR1 and mGluR5, and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.
Bibliographical noteFunding Information:
This study was supported by the Academy of Finland , Helsinki, Finland, the Sigrid Jusélius Foundation , Helsinki, Finland, the Center for International Mobility (CIMO), Helsinki, Finland, the Portuguese Foundation for Science and Technology , Lisbon, Portugal, and the Gulbenkian Foundation , Lisbon, Portugal.
- Aversive place-conditioning
- Descending pain modulation
- Emotional pain
- Mechanical pain sensibility
- Peripheral neuropathy