Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat

Osei B. Ansah, Nora Bourbia, Leonor Gonçalves, Armando Almeida, Antti Pertovaara*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR1 and mGluR5, and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.

Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalBehavioural Brain Research
Volume209
Issue number1
DOIs
Publication statusPublished - 1 May 2010
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the Academy of Finland , Helsinki, Finland, the Sigrid Jusélius Foundation , Helsinki, Finland, the Center for International Mobility (CIMO), Helsinki, Finland, the Portuguese Foundation for Science and Technology , Lisbon, Portugal, and the Gulbenkian Foundation , Lisbon, Portugal.

Keywords

  • Amygdala
  • Aversive place-conditioning
  • Descending pain modulation
  • Emotional pain
  • Mechanical pain sensibility
  • Peripheral neuropathy

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