Influence of prior meningococcal C polysaccharide vaccination on the response and generation of memory after meningococcal C conjugate vaccination in young children

Raymond Borrow, David Goldblatt, Nicholas Andrews, Peter Richmond, Joanna Southern, Elizabeth Miller

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

To determine whether the immunological hyporesponsiveness induced by meningococcal AC polysaccharide (MACP) vaccines can be overcome by meningococcal C conjugate (MCC) vaccine in young children, serum bactericidal antibody (SBA) serogroup C-specific IgG and IgG avidity indices were measured in young children who received MACP vaccine, followed 7 months later by MCC vaccine, and their responses were compared with those in age-matched MACP-naive control children, who received a single dose of MCC vaccine. For children <1 year of age at MACP vaccination, the SBA geometric mean titer (GMT) after MCC vaccination was lower (P = .022) and proportions with SBA titers <8 (P = .0083) or <128 (P = .0091) were higher than those in the control children. For older children, there was no difference in the SBA GMTs between the study and control groups (P > .5) or in the proportion with SBA titers <8 (P = 1.00) or <128 (P = .98). No increase in avidity occurred after MACP vaccination, whereas avidity increased significantly 1 month after MCC vaccination, with a further increase at 6 months, which indicates that the induction of immunological memory was not impaired.

Original languageEnglish
Pages (from-to)377-380
Number of pages4
JournalJournal of Infectious Diseases
Volume184
Issue number3
DOIs
Publication statusPublished - 1 Aug 2001
Externally publishedYes

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