Invasive Haemophilus influenzae disease, Europe, 1996-2006

Shamez Ladhani, Mary Slack, Paul T. Heath, Anne Von Gottberg, Manosree Chandra, Mary Ramsay, Peter McIntyre, Lyn Gilbert, Geoff Hogg, Reinhild Strauss, Sigrid Heuberger, Germaine Hanquet, Francoise Crokaert, Pavla Krizova, Vera Lebedova, Kåre Mølbak, Jens Jørgen Christensen, Kuulo Kutsar, Unna Joks, Elja HervaTarja Kaijalainen, Maija Leinonen, Petri Ruutu, Agnes Lepoutre, Henri Dabernat, Anette Siedler, Heinz J. Schmitt, Marie Theodoridou, Anastasia Pangalis, Georgina Tzanakaki, Miklos Fuzi, Katalin Krisztalovics, Thorolfur Gudnason, Hjordis Hardardottir, Mary Cafferkey, Suzanne Cotter, Darina O'Flanagan, Ron Dagan, Marina Cerquetti, Marta Ciofi Degli Atti, Irina Lucenko, Grazina Rimseliene, Snieguole Dauksiene, Pierette Huberty-Krau, Francois Schneider, Jackie Maistre Melillo, Sabine De Greeff, Hester De Melker, Lodewijk Spanjaard, Hans Blystad, E. Arne Hoiby, Øistein Løvoll, Andrzej Zielinski, Waleria Hryniewicz, Anna Skoczynska, Marcin Kadlubowski, Laurinda Queirós, Paula Lavado, Claire Cameron, Barbara Denham, Fiona Johnston, Margareta Slacikova, Elena Novakova, Alenka Kraigher, Metka Paragi, Jose Campos, Javier Diez-Domingo, Rose Marie Carlsson, Birgitta Henriques Normark, Hans Peter Zimmermann

    Research output: Contribution to journalArticlepeer-review

    154 Citations (Scopus)

    Abstract

    An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality.

    Original languageEnglish
    Pages (from-to)455-463
    Number of pages9
    JournalEmerging Infectious Diseases
    Volume16
    Issue number3
    DOIs
    Publication statusPublished - Mar 2010

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