Invasive pneumococcal disease in England and Wales: Vaccination implications

Karen Sleeman, Kyle Knox, Robert George, Elizbeth Miller, Pauline Waight, David Griffiths, Androulla Efstratiou, Karen Broughton, Richard T. Mayon-White, E. R. Moxon, D. W. Crook

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)


Knowledge of the epidemiology of invasive pneumococcal disease (IPD) will aid in planning the use of pneumococcal vaccines. A United Kingdom (UK)-based surveillance in England and Wales (1995-1997) of 11,528 individuals with IPD and a local enhanced surveillance in the Oxford (UK) area (1995-1999) have been analyzed. IPD has a high attack rate in children, with 37.1-48.1 cases per 100,000 infants <1 year old per year, and in older persons, with 21.2-36.2 cases per 100,000 persons >65 years old per year, for England, Wales, and Oxford. The 7-valent conjugate vaccine includes serotypes causing ≤79% of IPD in children <5 years old, but only 66% in adults >65 years old. The data also indicate that IPD varies by serotype, age, and country, emphasizing that the epidemiology of IPD is heterogeneous and requires continued surveillance.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalJournal of Infectious Diseases
Issue number2
Publication statusPublished - 15 Jan 2001

Bibliographical note

Funding Information:
Financial support: Public Health Laboratory Service; University Department of Paediatrics, Oxford, which is funded in part by Aventis Pasteur (to Oxford Vaccine Group).


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