An outline is presented of an electronically accessible database that compares the locations of mouse genes involved in DNA repair, apoptosis, cell cycle and signal transduction with those of known cancer risk modifier genes. The database has a primary but not exclusive focus on modifiers of ionizing radiation (IR) cancer risk and genes involved in IR-induced DNA damage responses. The database (http://www.hpa.org.uk/radiation/publications/ misc_publications/dna_database/dna_database.htm) provides a useful tool for assessing the role of DNA damage response genes in cancer predisposition. Crown
Bibliographical noteFunding Information:
The compilation of the database was funded by the European Commission through the Fifth Framework MAGELLANS contract (FIGH-CT-1999-00006) as a joint collaborative research project involving the former National Radiological Protection Board, now the Radiation Protection Division of the Health Protection Agency (United Kingdom), and Istituto Nazionale Tumori (INT, Italy).
Copyright 2008 Elsevier B.V., All rights reserved.
- DNA repair
- Ionizing radiation