There have been few long-term investigations of particle retention in the human lung. Investigations in which measurements are made up to about 100 days after inhalation have yielded clearance half-times in the range of 60-600 days. Longer-term experimental studies have shown that retention cannot be represented by a single exponential function and a multi-component pattern of clearance has also been found in investigations of accidental intakes of plutonium isotopes. The approach taken in the study reported in this paper has been to measure the retention of an inert, non-toxic material in human volunteers. Study objectives were to determine typical clearance kinetics, to investigate the effect of particle size on clearance and to assess the degree of variation between individuals. Experimental procedures and results are discussed. Refs.
|Number of pages||3|
|Journal||Journal of Aerosol Science|
|Publication status||Published - 1983|
|Event||Aerosols in Sci, Med and Technol, Abstr of the Annu Conf of the Assoc for Aerosol Res, 10th - Bologna, Italy|
Duration: 14 Sep 1982 → 17 Sep 1982