Lower respiratory tract infection in the first year of life is associated with worse lung function in adult life: Prospective results from the Barry Caerphilly Growth study

James A. Lopez Bernal, Mark N. Upton, A. John Henderson, Daniel Dedman, Anne McCarthy, George Davey Smith, Yoav Ben-Shlomo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Purpose: We examined the association between childhood respiratory infections and adult lung function and how this association varies depending on the age at infection. Methods: The Barry Caerphilly Growth study collected information on childhood upper and lower respiratory tract infections (URTI, LRTI) from birth to 5 years on 14 occasions. Subjects were traced prospectively and had lung function measured at age 25 years. Results: A total of 581 subjects had acceptable data for both forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Childhood LRTIs (0-5 years) but not URTIs were negatively associated with all lung function measures except FVC and showed a dose-response effect. In the first year of life, a two-fold increase in the number of LRTIs experienced was associated with a reduction in FEV1 (78 mL; 95% confidence interval [95% CI], 3-153), FEV1/FVC (1.23%; 95% CI 0.25-2.22), forced expiratory flow 25%-75% (0.25 l/sec; 95% CI 0.08-0.41), and peak expiratory flow (0.30 l/sec; 95% CI 0.11-0.49) after adjustment for confounders. Few associations were found after the first year of life. There was evidence that age at infection effect modifies the association between LRTIs and FEV1, forced expiratory flow 25%-75%, and peak expiratory flow. Conclusions: LRTIs are associated with an obstructive lung function deficit. Furthermore, the first year of life may be a sensitive period for experiencing LRTIs.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalAnnals of Epidemiology
Volume23
Issue number7
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

Bibliographical note

Funding Information:
We thank all of the participants in the original study and those who were willing to be followed up in early adulthood. We are also very grateful to all of the staff involved in the original study and who helped collect data, as well as Bro Taf Health Authority for helping us to contact the subjects. The original study was undertaken by Prof. Peter Elwood and the MRC Epidemiology Unit (Cardiff) funded by the Department of Health . The recent follow-up study was funded by grants from the British Lung Foundation ( P97/7 ), British Heart Foundation ( 97020 ), and British Diabetic Association ( 1192 ). Ethical approval for the study was granted by the Bro Taf Research Ethics Committee .

Keywords

  • Lifecourse epidemiology
  • Longitudinal studies
  • Lung function tests
  • Pediatric lung disease
  • Respiratory tract infections

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