Major uropathogenic Escherichia coli strain isolated in the Northwest of England identified by multilocus sequence typing

Ha Lau Siu, Suganya Reddy, John Cheesbrough, Frederick J. Bolton, Geraldine Willshaw, Thomas Cheasty, Andrew Fox, Mathew Upton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

130 Citations (Scopus)

Abstract

A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these isolates, 51 of which were resistant to extended-spectrum cephalosporins. ST-131 appears to be a drug-resistant uropathogenic strain of E. coli responsible for causing urinary tract infections and bacteremia and is widely disseminated among both community and hospital patients from different geographical areas in the northwest of England. Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. coli strains. The portability of MLST allows the accurate monitoring of this antibiotic-resistant uropathogenic strain of E. coli and will enhance surveillance for this important group of organisms.

Original languageEnglish
Pages (from-to)1076-1081
Number of pages6
JournalJournal of Clinical Microbiology
Volume46
Issue number3
DOIs
Publication statusPublished - Mar 2008

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