May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia?

Agnieszka Cecotka*, Lukasz Krol, Grainne O’Brien, Christophe Badie, Joanna Polanska

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

DNA methylation alteration is crucial for the initiation and development of Acute Myeloid Leukemia. However, only a few epigenetic biomarkers of AML have been discovered so far. DNA methylation of CpG rich gene promoters has the highest impact on gene expression level, so biomarkers should be sought in these genomic regions. Principal Component Analysis of methylation level reveals that male and female AML patients differ in CpG rich-gene promoters. Statistical comparison between males and females conducted for each CpG site confirms statistical relevance of differences only in CpG-rich promoter regions. P-value integration results in detection of AML-specific hypermethylated genomic regions and shows that almost 10% of CpG-rich promoters are differentially methylated between males and females. Functional analysis of genes with differentially methylated promoters in AML results in 322 enrichments for women and 1893 for men. Genes are mainly related to homeobox, cell development and morphogenesis. Survival analysis indentifies gender-specific potential epigenomic prognostic markers. Dissimilarity of the survival-significant gene sets between males and females is 75%.

Original languageEnglish
Title of host publicationPractical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021
EditorsMiguel Rocha, Florentino Fdez-Riverola, Mohd Saberi Mohamad, Roberto Casado-Vara
PublisherSpringer Science and Business Media Deutschland GmbH
Pages126-135
Number of pages10
ISBN (Print)9783030862572
DOIs
Publication statusPublished - 2022
Event15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021 - Salamanca, Spain
Duration: 6 Oct 20218 Oct 2021

Publication series

NameLecture Notes in Networks and Systems
Volume325 LNNS
ISSN (Print)2367-3370
ISSN (Electronic)2367-3389

Conference

Conference15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021
Country/TerritorySpain
CitySalamanca
Period6/10/218/10/21

Bibliographical note

Funding Information:
This work was financed by European Social Fund POWR.03.02.00-00-I029 (AC) and SUT grant no. 02/070/BK_21/0019 (LK, JP).

Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Keywords

  • Acute Myeloid Leukaemia
  • DNA methylation
  • Epigenetics
  • Prognostic markers
  • Sex disparity
  • Survival analysis

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