Meningococcal carriage and immunity in western Burkina Faso, 2003

Seydou Yaro, Yves Traoré, Zekiba Tarnagda, Lassana Sangaré, Berthe Marie NjanpopLafourcade, Aly Drabo, Helen Findlow, Raymond Borrow, Pierre Nicolas, Bradford D. Gessner, Judith E. Mueller

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A prospective carriage and serological study was conducted in Burkina Faso during the 2003 meningitis season, which was characterized by hyperendemic Neisseria meningitidis serogroup W135 (NmW135) and serogroup A (NmA) disease. Participants were evaluated five times at monthly intervals. In the presence of moderate NmW135 carriage, we found a low prevalence of putatively protective levels of specific immunoglobulin G (IgG) and serum bactericidal antibody (SBA) against NmW135. Specific IgG concentrations and SBA titers against NmA were relatively high in this recently vaccinated population, while no NmA carriage was detected. NmW135 carriage infrequently induced protective immunity against reference or homologous strains, while natural immunity against NmW135 was frequently lost. A vaccine that is effective against W135 will be beneficial for sub-Saharan Africa.

Original languageEnglish
Pages (from-to)A42-A46
JournalVaccine
Volume25
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 3 Sep 2007

Keywords

  • Carriage
  • Immunity
  • Neisseria meningitidis

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