Meningococcal serogroup A, B, C, W, X, and Y serum bactericidal antibody assays

Jay Lucidarme, Jennifer Louth, Kelly Townsend-Payne, Raymond Borrow

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

Serum bactericidal antibody (SBA) assays measure functional antibody titers against Neisseria meningitidis in sera. Induction of complement-dependent SBA after vaccination with meningococcal polysaccharide or conjugate or protein based vaccines is regarded as the surrogate of protection and thus acceptable evidence of the potential efficacy of these vaccines. This chapter discusses and details SBA assay protocols for measuring the complement-mediated lysis of serogroup A, B, C, W, X, and Y meningococci by human sera, for example, following vaccination or disease.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages169-179
Number of pages11
DOIs
Publication statusPublished - 2019

Publication series

NameMethods in Molecular Biology
Volume1969
ISSN (Print)1064-3745

Keywords

  • Bactericidal
  • Complement
  • Meningococcal
  • Neisseria meningitidis
  • Serum bactericidal antibody

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