Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe

Jack M. Crook, Ivana Murphy, Daniel Carter, Steven Pullan, Miles Carroll, Richard Vipond, Andrew A. Cunningham*, Diana Bell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The source of the COVID-19 pandemic is unknown, but the natural host of the progenitor sarbecovirus is thought to be Asian horseshoe (rhinolophid) bats. We identified and sequenced a novel sarbecovirus (RhGB01) from a British horseshoe bat, at the western extreme of the rhinolophid range. Our results extend both the geographic and species ranges of sarbecoviruses and suggest their presence throughout the horseshoe bat distribution. Within the spike protein receptor binding domain, but excluding the receptor binding motif, RhGB01 has a 77% (SARS-CoV-2) and 81% (SARS-CoV) amino acid homology. While apparently lacking hACE2 binding ability, and hence unlikely to be zoonotic without mutation, RhGB01 presents opportunity for SARS-CoV-2 and other sarbecovirus homologous recombination. Our findings highlight that the natural distribution of sarbecoviruses and opportunities for recombination through intermediate host co-infection are underestimated. Preventing transmission of SARS-CoV-2 to bats is critical with the current global mass vaccination campaign against this virus.

Original languageEnglish
Article number14723
JournalScientific Reports
Volume11
DOIs
Publication statusPublished - 19 Jul 2021

Bibliographical note

Funding Information: We thank Daniel Whitby, Animal Ecology and Wildlife Consultants Limited, for logistical support. This project was funded by Public Health England, the University of East Anglia and Research England. The views expressed in this publication are those of the authors and not the views of the National Health Service, the Department of Health and Social Care, Public Health England or any other institution.

Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Publisher Copyright: © The Author(s) 2021

Citation: Crook, J.M., Murphy, I., Carter, D.P. et al. Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe. Sci Rep 11, 14723 (2021).

DOI: https://doi.org/10.1038/s41598-021-94011-z

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