Molecular characterization and Panton-Valentine leucocidin typing of community-acquired methicillin-sensitive Staphylococcus aureus clinical isolates

Kome Otokunefor, Tim Sloan, Angela Kearns, Richard James

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Limited comprehensive molecular typing data exist currently for Panton-Valentine leucocidin (PVL)-positive, methicillin-sensitive Staphylococcus aureus (PVL-MSSA) clinical isolates. Characterization of PVL-MSSA isolates by multilocus sequence typing (MLST) and spa typing in this study showed a genetic similarity to PVL-positive, methicillin-resistant S. aureus (PVL-MRSA) strains, although three novel spa types and a novel MLST (ST1518) were detected. Furthermore, the detection of PVL phages and haplotypes in PVL-MSSA identical to those previously found in PVL-MRSA isolates highlights the role these strains may play as precursors of emerging lineages of clinical significance.

Original languageEnglish
Pages (from-to)3069-3072
Number of pages4
JournalJournal of Clinical Microbiology
Volume50
Issue number9
DOIs
Publication statusPublished - Sep 2012

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