Molecular mechanisms of radiation oncogenesis

Roger Cox*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Resolving the molecular mechanisms of radiation oncogenesis represents an important but daunting challenge in radiation research. This brief review outlines the principal oncogenic mechanisms that need to be considered in the context of radiation effects on the genome, how these might relate to specific gene and chromosomal changes relevant to neoplasia and the possible implications of such knowledge for the modelling of cancer risk. The long-term application of this mechanistic knowledge to the determination of tumour causality and for the assessment of individual cancer risk is also briefly discussed.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalInternational Journal of Radiation Biology
Volume65
Issue number1
DOIs
Publication statusPublished - 1994

Bibliographical note

Funding Information:
Work on radiation oncogenesis in the authors laboratory is partly supported by the Commission of the European Communities .

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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