New measles virus genotype associated with outbreak, China

Yan Zhang, Zhengrong Ding, Huiling Wang, Liqun Li, Yankun Pang, Kevin Brown, Songtao Xu, Zhen Zhu, Paul A. Rota, David Featherstone, Wenbo Xu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

To determine the origin of the virus associated with a measles outbreak in Menglian County, Yunnan Province, People's Republic of China, in 2009, we conducted genetic analyses. Phylogenetic analyses based on nucleoprotein (N) and hemagglutinin (H) gene sequences showed that these Menglian viruses were not closely related to sequences of any World Health Organization (WHO) reference strains representing the 23 currently recognized genotypes. The minimum nucleotide divergence between the Menglian viruses and the most closely related reference strain, genotype D7, was 3.3% for the N gene and 3.0% for the H gene. A search of the databases of GenBank, WHO, and the Health Protection Agency Measles Nucleotide Surveillance showed that the Menglian viruses, together with the 2 older non-Menglian viruses, could be members of a new proposed measles genotype, d11. The new genotype designation will allow for better description of measles transmission patterns, especially in the Southeast Asian and Western Pacific regions.

Original languageEnglish
Pages (from-to)943-947
Number of pages5
JournalEmerging Infectious Diseases
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 2010

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