Oseltamivir-resistant influenza viruses A (H1N1), Norway, 2007-08

Siri H. Hauge, Susanne Dudman, Katrine Borgen, Angie Lackenby, Olav Hungnes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

212 Citations (Scopus)

Abstract

In Norway in January 2008, unprecedented levels of os- eltamivir resistance were found in 12 of 16 influenza viruses A (H1N1) tested. To investigate the epidemiologic and clinical characteristics of these viruses, we used sequence analysis to test all available subtype H1N1 viruses from the 2007-08 season for resistance. Questionnaires from physicians provided information on predisposing diseases, oseltamivir use, symptoms, and complications. Clinical data were obtained for 265 patients. In total, 183 (67.3%) of 272 viruses were oseltamivir resistant. Resistance was not associated with prior use of antiviral drugs. Symptoms and hospitalization rates did not differ for patients infected with a resistant or a susceptible virus. Oseltamivir-resistant influenza viruses A (H1N1) did not show diminished capability to spread in the absence of selective pressure. The ability of these viruses to sustain their fitness and spread among persons should be considered when shaping future strategies for treating and preventing seasonal and pandemic influenza.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalEmerging Infectious Diseases
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2009

Bibliographical note

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

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