Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia

P. Hone, Alan Edwards, J. Halls, Roger Cox, D. Lloyd

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemogen by compromising DNA damage response to genotoxic agents such as ionising radiation. We examined this hypothesis using γ-ray-induced dicentric chromosome exchange in human lymphocytes. The results from 12 h post-γ-ray exposure to fields of 0.23, 0.47 and 0.7 mT provide no support to the hypothesis. The power of the study was sufficient to exclude an ELF enhancement of chromosomal exchange of 10-15% (2SE).

Original languageEnglish
Pages (from-to)1939-1941
Number of pages3
JournalBritish Journal of Cancer
Volume88
Issue number12
DOIs
Publication statusPublished - 16 Jun 2003

Keywords

  • Childhood leukaemia
  • Chromosome aberration
  • DNA repair
  • Electromagnetic fields

Fingerprint

Dive into the research topics of 'Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia'. Together they form a unique fingerprint.

Cite this