Post-exposure prophylaxis of systemic anthrax in mice and treatment with fluoroquinolones

J. A. Steward, M. S. Lever, Andrew Simpson, A. M. Sefton, Timothy Brooks

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Objectives: To compare the fluoroquinolones gatifloxacin and moxifloxacin with ciprofloxacin for post-exposure prophylaxis of systemic anthrax in a BALB/c mouse model. Methods: Treated mice and controls were inoculated subcutaneously with 5 × 104 spores/mouse of Bacillus anthracis Ames strain and observed for 37 days after challenge. Treated mice were given 100 mg/kg of antibiotic orally twice daily for 14 days, starting at various times post-challenge. Results: Treatment starting 6h post-challenge resulted in survival rates of 90%, 15% and 40% for gatifloxacin, moxifloxacin and ciprofloxacin, respectively. Treatment commencing 24h post-challenge resulted in survival rates of 65%, 10% and 5%, respectively. Treatment starting more than 24h after exposure had little effect on survival. Conclusions: Gatifloxacin appeared to be more effective than moxifloxacin or ciprofloxacin, at similar doses, for early post-exposure treatment of murine systemic anthrax. However, these results might be due to differences in potency or pharmacokinetic properties.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume54
Issue number1
DOIs
Publication statusPublished - Jul 2004

Bibliographical note

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Bacillus anthracis
  • Murine model
  • Quinolones
  • Therapy

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