Pre-emptive treatment for Clostridium tetani: Importance of early recognition and treatment in the community

Etienne Laverse, Kanchan Dhamija, Marilyn Meyers, Kathleen Grant

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3 Citations (Scopus)

Abstract

The case of a 79-year-old woman with neurotoxin producing Clostridium tetani identified in a lower limb laceration that was promptly treated is presented; the patient developed no symptoms of tetanus. Her antibody levels were measured as 0.01 U/ml (protective levels >0.01 U/ml) and were theref ore not protective. The isolate of C tetani was identified by 16S sequencing. The potential to produce tetanus toxin was determined by detection of a fragment of the C tetani neurotoxin gene. She was given a week long course of oral flucloxacillin, 500 mg four times a day and metronidazole, 400 mg three times a day, for 5 days. The patient was subsequently given prophylactic immunoglobulin (500 IU) as per guidelines. The f act that the patient did not manifest any symptoms of localised or generalised tetanus could be attributed to prompt management when she presented to her primary care site.

Original languageEnglish
Article number1649
JournalBMJ Case Reports
DOIs
Publication statusPublished - 11 Jun 2009

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