Presence of human herpesvirus 8 variants in the oral tissues of human immunodeficiency virus-infected persons

L. Di Alberti, Siew Lin Ngui, S. R. Porter, P. M. Speight, C. M. Scully, J. M. Zakrewska, I. G. Williams, L. Artese, A. Piattelli, C. G. Teo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

A 210-bp DNA segment specific to the human herpesvirus 8 (HHV-8) genome was amplified by nested polymerase chain reaction from 10 of 14 archived oral biopsy samples of HIV-positive patients in London who had no evidence of oral Kaposi's sarcoma (KS). Various oral sites were represented. Oral tissues from 20 general dental patients not known to be HIV-infected were negative. When DNA sequences of these products were compared with sequences derived from 5 oral KS tissues of AIDS patients in London and 10 skin biopsies of Italian patients with Mediterranean KS (total number of positive tissues = 25), 11 were found to be unique. DNA and predicted peptide motifs of these sequences were also different from those in 28 of 36 HHV-8-positive lesions previously reported from American and African patients. HHV-8 is tropic for the oral mucosa of HIV-infected persons, and HHV-8 variants, though diverse, may be geographically restricted.

Original languageEnglish
Pages (from-to)703-707
Number of pages5
JournalJournal of Infectious Diseases
Volume175
Issue number3
DOIs
Publication statusPublished - 1997

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