Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine

Kate Griffin, Richard Bedford, Kate Townson, Robert Phillpotts, Simon Funnell, Margret Morton, Diane Williamson, Richard Titball

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Vaccines against bioterrorism agents offer the prospect of providing high levels of protection against airborne pathogens. However, the diversity of the bioterrorism threat means that it may be necessary to use several vaccines simultaneously. In this study we have investigated whether there are changes to the protective immune response to a recombinant sub-unit plague vaccine when it is co-administered with other sub-unit or live attenuated vaccines. Our results indicate that the co-administration of these vaccines did not influence the protection afforded by the plague vaccine. However, the co-administration of the plague sub-unit vaccine with a live vaccine resulted in markedly increased levels of IgG2a subclass antibodies, and markedly reduced levels of IgG1 subclass antibodies, to the plague sub-unit vaccine. This finding might have implications when considering the co-administration of other vaccine combinations.

Original languageEnglish
Pages (from-to)425-430
Number of pages6
JournalFEMS Immunology and Medical Microbiology
Volume43
Issue number3
DOIs
Publication statusPublished - 1 Mar 2005

Keywords

  • Co-administration
  • Plague
  • Vaccines

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