Quantifying where human acquisition of antibiotic resistance occurs: A mathematical modelling study

Gwenan M. Knight*, Céire Costelloe, Sarah R. Deeny, Luke S.P. Moore, Susan Hopkins, Alan P. Johnson, Julie V. Robotham, Alison H. Holmes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Background: Antibiotic-resistant bacteria (ARB) are selected by the use of antibiotics. The rational design of interventions to reduce levels of antibiotic resistance requires a greater understanding of how and where ARB are acquired. Our aim was to determine whether acquisition of ARB occurs more often in the community or hospital setting. Methods: We used a mathematical model of the natural history of ARB to estimate how many ARB were acquired in each of these two environments, as well as to determine key parameters for further investigation. To do this, we explored a range of realistic parameter combinations and considered a case study of parameters for an important subset of resistant strains in England. Results: If we consider all people with ARB in the total population (community and hospital), the majority, under most clinically derived parameter combinations, acquired their resistance in the community, despite higher levels of antibiotic use and transmission of ARB in the hospital. However, if we focus on just the hospital population, under most parameter combinations a greater proportion of this population acquired ARB in the hospital. Conclusions: It is likely that the majority of ARB are being acquired in the community, suggesting that efforts to reduce overall ARB carriage should focus on reducing antibiotic usage and transmission in the community setting. However, our framework highlights the need for better pathogen-specific data on antibiotic exposure, ARB clearance and transmission parameters, as well as the link between carriage of ARB and health impact. This is important to determine whether interventions should target total ARB carriage or hospital-acquired ARB carriage, as the latter often dominated in hospital populations.

Original languageEnglish
Article number137
JournalBMC Medicine
Volume16
Issue number1
DOIs
Publication statusPublished - 23 Aug 2018

Bibliographical note

Funding Information:
The work was supported by the NIHR Health Protection Research Unit (HPRU) in Healthcare Associated Infections and Antimicrobial Resistance at Imperial College London in partnership with Public Health England (PHE). The views expressed are those of the author(s) and not necessarily those of the National Health Service (NHS), the NIHR, the Department of Health or PHE.

Funding Information:
The authors also wish to acknowledge support from the National Institute for Health Research (NIHR) Imperial Biomedical Research Centre provided to LSPM and AHH.

Publisher Copyright:
© 2018 The Author(s).

Keywords

  • Antibiotic resistance
  • Community
  • Hospital
  • Intervention design
  • Mathematical modelling
  • Resistance acquisition

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