Ralstonia infection in cystic fibrosis

H. D. Green*, R. Bright-Thomas, D. T. Kenna, Jane Turton, Neil Woodford, A. M. Jones

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Summary This study aimed to determine prevalence of Ralstonia spp. in cystic fibrosis patients, look for any evidence of cross infection and to describe clinical outcomes for patients infected by Ralstonia spp. Prevalence of Ralstonia spp. was calculated annually from 2008 to 2016. Pulsed-field gel electrophoresis was performed on ≥1 sample from patients with an isolation of Ralstonia spp. between 2008 and 2016. A prospective, longitudinal observational study of adult patients was performed with 12 months follow-up from recruitment. Prevalence of Ralstonia spp. rose from 0·6% in 2008 to 2·4% in 2016. In total 12 out of 14 (86%) patients with ≥1 isolation of Ralstonia spp. developed chronic infection. A pair and a group of three unrelated patients with epidemiological connections shared strains of Ralstonia mannitolilytica. Lung function of Ralstonia spp. infected patients was moderately to severely impaired. Prevalence of Ralstonia spp. is low but increasing. The risk of a patient developing chronic Ralstonia spp. infection following first acquisition is high and cross-infection may be possible. Whether Ralstonia spp. infection causes increased pulmonary exacerbation frequency and lung function decline needs to be evaluated in larger prospective studies.

Original languageEnglish
Pages (from-to)2864-2872
Number of pages9
JournalEpidemiology and Infection
Volume145
Issue number13
DOIs
Publication statusPublished - 1 Oct 2017

Bibliographical note

Publisher Copyright:
Copyright © Cambridge University Press 2017.

Keywords

  • Bacterial typing
  • hospital infection
  • molecular epidemiology

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