Recombinant MVA vaccines: Dispelling the myths

Matthew G. Cottingham, Miles Carroll

    Research output: Contribution to journalArticlepeer-review

    64 Citations (Scopus)

    Abstract

    Diseases such as HIV/AIDS, tuberculosis, malaria and cancer are prime targets for prophylactic or therapeutic vaccination, but have proven partially or wholly resistant to traditional approaches to vaccine design. New vaccines based on recombinant viral vectors expressing a foreign antigen are under intense development for these and other indications. One of the most advanced and most promising vectors is the attenuated, non-replicating poxvirus MVA (modified vaccinia virus Ankara), a safer derivative of the uniquely successful smallpox vaccine. Despite the ability of recombinant MVA to induce potent humoral and cellular immune responses against transgenic antigen in humans, especially when used as the latter element of a heterologous prime-boost regimen, doubts are occasionally expressed about the ultimate feasibility of this approach. In this review, five common misconceptions over recombinant MVA are discussed, and evidence is cited to show that recombinant MVA is at least sufficiently genetically stable, manufacturable, safe, and immunogenic (even in the face of prior anti-vector immunity) to warrant reasonable hope over the feasibility of large-scale deployment, should useful levels of protection against target pathogens, or therapeutic benefit for cancer, be demonstrated in efficacy trials.

    Original languageEnglish
    Pages (from-to)4247-4251
    Number of pages5
    JournalVaccine
    Volume31
    Issue number39
    DOIs
    Publication statusPublished - 6 Sep 2013

    Keywords

    • Genetic vaccine
    • HIV
    • Malaria
    • Modified vaccinia virus Ankara (MVA)
    • Poxvirus
    • Recombinant
    • Tuberculosis
    • Vaccine
    • Vaccinia virus
    • Vector

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