Recombinant protein meningococcal serogroup B vaccine combined with outer membrane vesicles

Xilian Bai*, Jamie Findlow, Raymond Borrow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

Meningococcal infection is a major cause of morbidity and mortality worldwide. Infection with Neisseria meningitidis is most common in young children, teenagers and people with certain medical conditions. Effective polysaccharide and glycoconjugate vaccines for serogroups A, C, W135 and Y have been developed. A similar capsular polysaccharide approach for serogroup B (MenB) has by most been judged as unsuitable, hence, no broad coverage vaccine has been licensed to date. The novel vaccine Bexsero (previously 4CMenB) has been developed and proven safe and immunogenic in clinical trials. Areas covered: The authors outline the constituents of Bexsero and immunogenicity and safety data from preclinical and clinical trials published in peer-reviewed literature, meeting proceedings and publicly-available clinical trial websites from 2000 to 2010. Expert opinion: Bexsero is well tolerated with a proven safety profile, and has demonstrated a robust immune response across different age groups against a range of diverse MenB strains. These data suggest that Bexsero has the ability to provide protection in infants, who are at the greatest risk of developing meningococcal disease.

Original languageEnglish
Pages (from-to)969-985
Number of pages17
JournalExpert Opinion on Biological Therapy
Volume11
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Bexsero®
  • factor H binding protein (fHbp)
  • four component meningococcal serogroup B (4CMenB) vaccine
  • meningococcal serogroup B (MenB)
  • Neisserial adhesin A (NadA)
  • Neisserial heparin-binding antigen (NHBA)
  • Outer Membrane Vesicles (OMVs)
  • vaccine

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