Response to antiretroviral therapy (ART): Comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women

Susie Huntington*, Claire Thorne, Jane Anderson, Marie Louise Newell, Graham P. Taylor, Deenan Pillay, Teresa Hill, Pat Tookey, Caroline Sabin, Jonathan Ainsworth, Abdel Babiker, David Chadwick, Valerie Delpech, David Dunn, Martin Fisher, Sophie Jose, Brian Gazzard, Richard Gilson, Phillip Hay, Mark GompelsMargaret Johnson, Stephen Kegg, Clifford Leen, Mark Nelson, Chloe Orkin, Adrian Palfreeman, Andrew Phillips, Frank Post, Memory Sachikonye, Achim Schwenk, John Walsh, Alicia Thornton, Adam Glabay, Nigel Garrett, Janet Lynch, James Hand, Carl de Souza, Nicky Perry, Stuart Tilbury, Elaney Youssef, Duncan Churchill, Matthew Waxman, David Asboe, Sundhiya Mandalia, Sajid Munshi, Damilola Awosika, Hardik Korat, Chris Taylor, Zachary Gleisner, Fowzia Ibrahim, Lucy Campbell, Kirsty Baillie, Nataliya Brima, Ian Williams, Sheila Miller, Chris Wood, Mike Youle, Fiona Lampe, Colette Smith, Helen Grabowska, Clinton Chaloner, Jonathan Weber, Farhan Ramzan, Mark Carder, Alan Wilson, Sue Allan, Anne Moore, Lynn Fox, Josef Bojanowski, Paul Main, Dr Mitchell, Dr Hunter, Mandip Dhillon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started.Methods: Data were obtained by linking two UK studies: the UK Collaborative HIV Cohort (UK CHIC) study and the National Study of HIV in Pregnancy and Childhood (NSHPC). Treatment responses were assessed for 2028 women initiating ART at least one year after HIV-diagnosis. Outcomes were compared using logistic regression, proportional hazards regression or linear regression.Results: In adjusted analyses, ART-naïve (n = 1937) and ZDVm-experienced (n = 91) women had similar increases in CD4 count and a similar proportion achieving virological suppression; both groups had a low risk of AIDS.Conclusions: In this setting, antenatal ZDVm exposure did not adversely impact on outcomes once ART was initiated for the woman's health.

Original languageEnglish
Article number127
JournalBMC Infectious Diseases
Volume14
Issue number1
DOIs
Publication statusPublished - 4 Mar 2014

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Antiretroviral therapy
  • HIV
  • Pregnancy
  • United Kingdom

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