Based on data from 14 Supranational Tuberculosis (TB) Reference Laboratories worldwide, the proportion of rifampicin (RMP) resistant isolates that were isoniazid (INH) susceptible by phenotypic drug susceptibility testing varied widely (0.5-11.6%). RMP-resistant isolates that were INH-susceptible had significantly lower rates of resistance to other first- and second-line anti-tuberculosis drugs (except rifabutin) compared to multidrug-resistant isolates. RMP resistance is not a lways a good proxy for a presumptive diagnosis of multidrug-resistant TB, which has implications for use of molecular assays that identify only RMP resistanceassociated DNA mutations.
|Number of pages||3|
|Journal||International Journal of Tuberculosis and Lung Disease|
|Publication status||Published - 1 Mar 2012|
Copyright 2013 Elsevier B.V., All rights reserved.
- Drug resistance
- Molecular diagnostic tests
- Rifampicin resistance