Risk of Lung Cancer Mortality in Nuclear Workers from Internal Exposure to Alpha Particle-emitting Radionuclides

James Grellier, Will Atkinson, Philippe Bérard, Derek Bingham, Alan Birchall, Eric Blanchardon, Richard Bull, Irina Guseva Canu, Cécile Challeton-De Vathaire, Rupert Cockerill, Minh T. Do, Hilde Engels, Jordi Figuerola, Adrian Foster, Luc Holmstock, Christian Hurtgen, Dominique Laurier, Matthew Puncher, Anthony E. Riddell, Eric SamsonIsabelle Thierry-Chef, Margot Tirmarche, Martine Vrijheid, Elisabeth Cardis

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Carcinogenic risks of internal exposures to alpha-emitters (except radon) are poorly understood. Since exposure to alpha particles - particularly through inhalation - occurs in a range of settings, understanding consequent risks is a public health priority. We aimed to quantify dose-response relationships between lung dose from alpha-emitters and lung cancer in nuclear workers. Methods: We conducted a case-control study, nested within Belgian, French, and UK cohorts of uranium and plutonium workers. Cases were workers who died from lung cancer; one to three controls were matched to each. Lung doses from alpha-emitters were assessed using bioassay data. We estimated excess odds ratio (OR) of lung cancer per gray (Gy) of lung dose. Results: The study comprised 553 cases and 1,333 controls. Median positive total alpha lung dose was 2.42 mGy (mean: 8.13 mGy; maximum: 316 mGy); for plutonium the median was 1.27 mGy and for uranium 2.17 mGy. Excess OR/Gy (90% confidence interval) - adjusted for external radiation, socioeconomic status, and smoking - was 11 (2.6, 24) for total alpha dose, 50 (17, 106) for plutonium, and 5.3 (-1.9, 18) for uranium. Conclusions: We found strong evidence for associations between low doses from alpha-emitters and lung cancer risk. The excess OR/Gy was greater for plutonium than uranium, though confidence intervals overlap. Risk estimates were similar to those estimated previously in plutonium workers, and in uranium miners exposed to radon and its progeny. Expressed as risk/equivalent dose in sieverts (Sv), our estimates are somewhat larger than but consistent with those for atomic bomb survivors. See video abstract at, http://links.lww.com/EDE/B232.

Original languageEnglish
Pages (from-to)675-684
Number of pages10
JournalEpidemiology
Volume28
Issue number5
DOIs
Publication statusPublished - 1 Sep 2017

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