SARS transmission in Vietnam outside of the health-care setting

P. A. Tuan, Peter Horby, P. N. Dinh, L. T.Q. Mai, Maria Zambon, J. Shah, V. Q. Huy, S. Bloom, R. Gopal, J. Comer, A. Plant

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

To evaluate the risk of transmission of SARS coronavirus outside of the health-care setting, close household and community contacts of laboratory-confirmed SARS cases were identified and followed up for clinical and laboratory evidence of SARS infection. Individual- and household-level risk factors for transmission were investigated. Nine persons with serological evidence of SARS infection were identified amongst 212 close contacts of 45 laboratory- confirmed SARS cases (secondary attack rate 4.2%, 95% CI 1.5-7). In this cohort, the average number of secondary infections caused by a single infectious case was 0.2. Two community contacts with laboratory evidence of SARS coronavirus infection had mild or sub-clinical infection, representing 3% (2/65) of Vietnamese SARS cases. There was no evidence of transmission of infection before symptom onset. Physically caring for a symptomatic laboratory-confirmed SARS case was the only independent risk factor for SARS transmission (OR 5.78, 95% CI 1.23-24.24).

Original languageEnglish
Pages (from-to)392-401
Number of pages10
JournalEpidemiology and Infection
Volume135
Issue number3
DOIs
Publication statusPublished - Apr 2007

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