Sensitivity and latency of ionising radiation-induced cataract

Elizabeth A. Ainsbury, Stephen G.R. Barnard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

When managed with appropriate radiation protection procedures, ionising radiation is of great benefit to society. Opacification of the lens, and vision impairing cataract, have recently been recognised at potential effects of relatively low dose radiation exposure, on the order of 1 Gy or below. Within the last 10 years, understanding of the effects of low dose ionising radiation on the lens has increased, particularly in terms of DNA damage and responses, and how multiple radiation or other events in the lens might contribute to the overall risk of cataract. However, gaps remain, not least in the understanding of how radiation interacts with other risk factors such as aging, as well as the relative radiosensitivity of the lens compared to tissues of the body. This paper reviews the current literature in the field of low dose radiation cataract, with a particular focus on sensitivity and latency.

Original languageEnglish
Article number108772
JournalExperimental Eye Research
Volume212
Early online date22 Sep 2021
DOIs
Publication statusE-pub ahead of print - 22 Sep 2021

Bibliographical note

Funding Information: No funding Information

Open Access: No Open Access licence.

Publisher Copyright: Crown Copyright © 2021 Published by Elsevier Ltd. All rights reserved.

Citation: Elizabeth A. Ainsbury, Stephen G.R. Barnard, Sensitivity and latency of ionising radiation-induced cataract, Experimental Eye Research, Volume 212, 2021, 108772, ISSN 0014-4835.

DOI: https://doi.org/10.1016/j.exer.2021.108772.

Keywords

  • Cataract
  • DNA Damage
  • Ionising radiation
  • Lens
  • Radiosensitivity

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