Sensitivity testing of an age-related, multicompartment dosimetric model for bone-surface-seeking radionuclides in man

N. D. Priest*, Alan Birchall

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The sensitivity testing of an age-related dosimetric model and its application to the dosimetry of239Pu are described. The model is used to calculate the committed dose received by the skeleton and liver to age 70 y, following intakes of239Pu by an adult aged 20 y and by children aged 0 and 10 y. The model is biologically based and takes account of the age-dependent transfer of Pu between the different organs of the body and between the different components of the skeleton. It consists of 22 compartments, 16 of which are skeletal, each connected by transfer pathways defined by age-dependent rate constants. The sensitivity of the predictions of the model, as applied to adults, to changes in the assumed values of rate constants were tested. The results of the tests applied suggested that the age-related model is relatively robust and is not particularly sensitive to changes in the assumed values of many of the rate constants used.

Original languageEnglish
Pages (from-to)229-242
Number of pages14
JournalHealth Physics
Volume57
DOIs
Publication statusPublished - Jul 1989

Bibliographical note

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

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