Sero-epidemiological patterns of Epstein-Barr and herpes simplex (HSV-1 and HSV-2) viruses in England and Wales

Marianne C. Morris*, W. John Edmunds, Louise M. Hesketh, Andrew J. Vyse, Elizbeth Miller, Peter Morgan-Capner, David Brown

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


The aim was to carry out a population-based seroprevalence survey of Epstein-Barr virus (EBV) across a wide age range in England and Wales and to identify any associations between EBV and herpes simplex virus types one and two (HSV-1 and 2). Sera from an age-stratified sample of 2,893 individuals, submitted for diagnostic purposes to 15 public health laboratories in England and Wales in 1994, were tested for immunoglobulin G (IgG) antibody to EBV. The samples had been tested previously for IgG antibody to HSV-1 and HSV-2. The serological profile of EBV was consistent with an endemic infection with peaks in transmission in those less than 5 years old and in young adults. An age adjusted analysis found a significant association between EBV and HSV-1 seropositivity that is most likely explained by similarities in their mode of transmission. The very low seroprevalence of HSV-2 in this sample complicated the comparisons of EBV and HSV-1 with HSV-2. Any associations were most likely explained by chance. Given the association between EBV and HSV-1, it is likely that recently documented epidemiological changes in HSV-1 also apply to EBV. Continuing surveillance of these herpes viruses is necessary as the predicted changes could have a significant public health impact, especially in the young adult population.

Original languageEnglish
Pages (from-to)522-527
Number of pages6
JournalJournal of Medical Virology
Issue number4
Publication statusPublished - 2002


  • Association between viruses
  • Herpes viruses
  • Seroprevalence


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