Seroepidemiologic study of pandemic (H1N1) 2009 during outbreak in boarding school, England

Sandra Johnson, Chikwe Ihekweazu, Pia Hardelid, Nika Raphaely, Katja Hoschler, Alison Bermingham, Muhammad Abid, Richard Pebody, Graham Bickler, John Watson, Eamonn O'Moore

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We conducted a seroepidemiologic study during an outbreak of pandemic (H1N1) 2009 in a boarding school in England. Overall, 353 (17%) of students and staff completed a questionnaire and provided a serum sample. The attack rate was 40.5% and 34.1% for self-reported acute respiratory infection (ARI). Staff were less likely to be seropositive than students 13-15 years of age (staff 20-49 years, adjusted odds ratio [AOR] 0.30; >50 years AOR 0.20). Teachers were more likely to be seropositive than other staff (AOR 7.47, 95% confi dence interval [CI] 2.31-24.2). Of seropositive persons, 44.6% (95% CI 36.2%-53.3%) did not report ARI. Conversely, of 141 with ARI and 63 with infl uenza-like illness, 45.8% (95% CI 37.0%-54.0%) and 30.2% (95% CI 19.2%-43.0%) had negative test results, respectively. A weak association was found between seropositivity and a prophylactic dose of antiviral agents (AOR 0.55, 95% CI 0.30-0.99); prophylactic antiviral agents lowered the odds of ARI by 50%.

Original languageEnglish
Pages (from-to)1670-1677
Number of pages8
JournalEmerging Infectious Diseases
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2011

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