Seroprevalence and virologic surveillance of enterovirus 71 and coxsackievirus A6, United Kingdom, 2006-2017

Everlyn Kamau*, Dung Nguyen, Cristina Celma, Soile Blomqvist, Peter Horby, Peter Simmonds, Heli Harvala

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Enterovirus A71 (EV-A71) and coxsackievirus A6 (CVA6) cause hand, foot and mouth disease (HFMD) and are occasionally linked to severe neurologic complications and large outbreaks worldwide. We estimated EV-A71 and CVA6 seroprevalence using cross-sectional agestratified samples collected in 2006, 2011, and 2017. Seroprevalences of EV-A71 and CVA6 increased from 32% and 54% at 6-11 months to >75% by 10 years of age. Antibody titers declined after 20 years, which could indicate infrequent re-exposure in older populations. Age profiles for acquiring infections and mean titers were comparable in the 3 testing years, despite the marked increase in incidence of CVA6-related HFMD from 2010. The uncoupling of changes in disease severity from the infection kinetics of CVA6 as we inferred from the seroprevalence data, rather than incidence of infection over the 11-year study period, provides further evidence for a change in its pathogenicity.

Original languageEnglish
Pages (from-to)2261-2268
Number of pages8
JournalEmerging Infectious Diseases
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 2021

Bibliographical note

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© 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.

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