Severity of COVID-19 in children with cancer: Report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project

Gerard C. Millen*, Roland Arnold, Jean Baptiste Cazier, Helen Curley, Richard G. Feltbower, Ashley Gamble, Adam W. Glaser, Richard G. Grundy, Lennard Y.W. Lee, Martin G. McCabe, Robert S. Phillips, Charles Stiller, Csilla Várnai, Pamela R. Kearns

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background: Children with cancer are frequently immunocompromised. While children are generally thought to be at less risk of severe SARS-CoV-2 infection than adults, comprehensive population-based evidence for the risk in children with cancer is unavailable. We aimed to produce evidence of the incidence and outcomes from SARS-CoV-2 in children with cancer attending all hospitals treating this population across the UK. Methods: Retrospective and prospective observational study of all children in the UK under 16 diagnosed with cancer through data collection from all hospitals providing cancer care to this population. Eligible patients tested positive for SARS-CoV-2 on reverse transcription polymerase chain reaction (RT-PCR). The primary end-point was death, discharge or end of active care for COVID-19 for those remaining in hospital. Results: Between 12 March 2020 and 31 July 2020, 54 cases were identified: 15 (28%) were asymptomatic, 34 (63%) had mild infections and 5 (10%) moderate, severe or critical infections. No patients died and only three patients required intensive care support due to COVID-19. Estimated incidence of hospital identified SARS-CoV-2 infection in children with cancer under 16 was 3%. Conclusions: Children with cancer with SARS-CoV-2 infection do not appear at increased risk of severe infection compared to the general paediatric population. This is reassuring and supports the continued delivery of standard treatment.

Original languageEnglish
Pages (from-to)754-759
Number of pages6
JournalBritish Journal of Cancer
Volume124
Issue number4
DOIs
Publication statusPublished - 16 Feb 2021

Bibliographical note

Funding Information:
Funding information University of Birmingham provided the database and bioinformatics support, G.M. is partially funded by a Cancer Research UK grant (A30259). This paper presents independent research supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (Grant Reference Number BRC-1215-20009). The views expressed are those of the author(s) and not necessarily those of the NIHR, Public Health England or the Department of Health and Social Care.

Publisher Copyright:
© 2020, The Author(s).

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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