Shared common ancestry of rodent alphacoronaviruses sampled globally

Theocharis Tsoleridis, Joseph G. Chappell, Okechukwu Onianwa, Denise A. Marston, Anthony R. Fooks, Elodie Monchatre-Leroy, Gérald Umhang, Marcel A. Müller, Jan F. Drexler, Christian Drosten, Rachael E. Tarlinton, Charles P. McClure, Edward C. Holmes, Jonathan K. Ball*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relative frequencies of virus-host co-divergence and cross-species transmission, we recovered longer fragments of CoV genomes from previously discovered European rodent alpha-CoVs using a combination of PCR and high-throughput sequencing. Accordingly, the full genome sequence was retrieved from the UK rat coronavirus, along with partial genome sequences from the UK field vole and Poland-resident bank vole CoVs, and a short conserved ORF1b fragment from the French rabbit CoV. Genome and phylogenetic analysis showed that despite their diverse geographic origins, all rodent alpha-CoVs formed a single monophyletic group and shared similar features, such as the same gene constellations, a recombinant beta-CoV spike gene, and similar core transcriptional regulatory sequences (TRS). These data suggest that all rodent alpha CoVs sampled so far originate from a single common ancestor, and that there has likely been a long-term association between alpha CoVs and rodents. Despite this likely antiquity, the phylogenetic pattern of the alpha-CoVs was also suggestive of relatively frequent host-jumping among the different rodent species.

Original languageEnglish
Article number125
JournalViruses
Volume11
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019
Externally publishedYes

Bibliographical note

Funding Information:
This study was funded by a Biotechnology and Biological Sciences Research Council Doctoral Training Partnership (BBSRC-DTP). ECH is supported by an ARC Australian Laureate Fellowship (FL170100022). JFD is supported by the European Union’s Horizon 2020 research and innovation program through the COMPARE project (grant agreement no. 643476).

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Alphacoronavirus
  • Ancestry
  • Coronavirus
  • Evolution
  • Recombination
  • Rodents

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