Sister-chromatid exchanges induced by mitomycin C after acute or chronic exposure of human lymphocytes to a low dose of X-rays

Jayne Moquet, J. S. Prosser, Alan Edwards, D. C. Lloyd

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Human peripheral blood lymphocytes from 10 male donors were exposed to mitomycin C with and without prior irradiation with 0.01 Gy X-rays. Acute or chronic irradiation of lymphocytes in G1 resulted in a decrease in the subsequent level of mitomycin C-induced sister-chromatid exchange aberrations. The effect was small (∼ 10%) with evidence of some variability between donors. By contrast no adaptive response was observed if the cells were treated in G0.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalMutation Research Letters
Volume227
Issue number4
DOIs
Publication statusPublished - Dec 1989

Keywords

  • Lymphocytes, human, X-ray exposure
  • Mitomycin C
  • Sister-chromatid exchanges

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