Stimulation of rat satellite cell myogenesis by inhibitors of ser/thr protein kinases

Catherine Lagord*, Gilles Carpentier, Marie Pierre Leibovitch, Jean Gautron, Isabelle Martelly

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Satellite cells are involved in physiological growth and post-traumatic regeneration of adult skeletal muscle fibres. In this study, it is shown that differentiation of primary cultures of rat satellite cells is increased by inhibitors of ser/thr protein kinases such as iso-H7, which both inhibit cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) activities, and HA1004, a PKA inhibitor. These results, showing a preponderant effect of PKA inhibition on myogenesis in vitro, prompted the effects of iso-H7 on muscular regeneration in vivo to be tested. Preliminary results showed that regeneration of rat muscle EDL was improved by iso-H7 treatment.

Original languageEnglish
Pages (from-to)379-383
Number of pages5
JournalNeuromuscular Disorders
Volume3
Issue number5-6
DOIs
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • cAMP-dependent protein kinase
  • myogenesis
  • regeneration
  • Satellite cells

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