Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B

Carmen L. Sheppard, Bruno Pichon, Robert George, Lucinda M.C. Hall

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Four Streptococcus pneumoniae isolates expressing both 6A and 6B capsular serotypes were detected by a multiplex immunoassay. The sequence of WciP, a GT2-family glycosyltransferase, indicates that point mutation has compromised linkage specificity, allowing two alternative oligosaccharides to be synthesized. This finding highlights that mutation as well as recombination can mediate serotype change.

Original languageEnglish
Pages (from-to)1820-1822
Number of pages3
JournalClinical and Vaccine Immunology
Volume17
Issue number11
DOIs
Publication statusPublished - Nov 2010

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