Structural modification of a base disaccharide alters antiadhesion properties towards Yersinia pestis

Richard J. Thomas, Andrew Hacking, Timothy Brooks

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Incubation in the presence of structurally modified disaccharides altered the in vitro attachment of Yersinia pestis GB to three human respiratory epithelial cell lines. Each disaccharide resulted in decreased attachment to the alveolar epithelial (A549) cell line. The best inhibitor of attachment for each cell line was the benzylated derivative of Galβ1-4GalNAc. Highly negatively charged saccharides were efficient inhibitors, particularly for the bronchial epithelial (BEAS2-B) cell line. The data indicate that targeted modification of receptor ligands could offer a novel therapeutic preventing Y. pestis attachment to host cells.

Original languageEnglish
Pages (from-to)410-414
Number of pages5
JournalFEMS Immunology and Medical Microbiology
Volume49
Issue number3
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Attachment
  • Galactosucrose
  • Inhibition
  • Yersinia pestis

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