Survival patterns in teenagers and young adults with cancer in the United Kingdom: Comparisons with younger and older age groups

Dan Stark, David Bowen, Elaine Dunwoodie, Richard Feltbower, Rod Johnson, Anthony Moran, Charles Stiller, Catherine O'Hara

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Aims We aimed to describe and compare survival in teenagers and young adults (TYAs) with cancer to that of younger children and older adults, to identify sub-populations at greater or lesser risk of death. Methods We compared survival in cancer patients diagnosed in the United Kingdom aged 13-24 years (TYAs) to those aged 0-12 (children) and 25-49 years (adults) using the National Cancer Data Repository. All cases had a first cancer diagnosis between 1st January 2001 and 31st December 2005 with censor date 31st December 2010 or death if earlier. Results We found six distinct statistically significant survival patterns. In pattern 1, the younger the age-group the better the 1- and 5-year survival (acute lymphoid leukaemia, carcinoma of ovary and melanoma). In pattern 2, TYAs had a worse 5-year survival than both children and young adults (bone and soft tissues sarcomas). In pattern 3, TYAs had a worse 1-year survival but no difference at 5-years (carcinoma of cervix and female breast). In pattern 4, TYAs had better 1-year survival than adults, but no difference at 5 years (carcinoma of liver and intrahepatic bile ducts, germ cell tumours of extra-gonadal sites). In pattern 5, the younger the age-group the better the 5-year survival, but the difference developed after 1-year (acute myeloid leukaemia, carcinoma of colon and rectum). In pattern 6, there was no difference in 1- and 5-year survival between TYAs and adults (testicular germ cell tumours, ovarian germ cell tumours and carcinoma of thyroid). Conclusion TYAs with specific cancer diagnoses can be grouped according to 1- and 5-year survival patterns compared to children and young adults. To further improve survival for TYAs, age-specific biology, pharmacology, proteomics, genomics, clinician and patient behaviour studies embedded within clinical trials are required.

Original languageEnglish
Pages (from-to)2643-2654
Number of pages12
JournalEuropean Journal of Cancer
Volume51
Issue number17
DOIs
Publication statusPublished - 2015

Keywords

  • Adolescent
  • Bone tumours
  • Cancer survival
  • Central nervous system tumours
  • Haematological malignancies
  • Neoplasms
  • Survival analysis
  • Teenage
  • Teenager and young adult cancer
  • Young adult

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