Synchronous recurrence of group B streptococcal late-onset sepsis in twins

Roland Elling, Markus Hufnagel, Aruni De Zoysa, Fabian Lander, Katharina Zumstein, Marcus Krueger, Philipp Henneke*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Group B Streptococcus (GBS) remains the leading cause of neonatal sepsis and meningitis in industrialized countries. Whereas the use of intrapartum antibiotic prophylaxis has led to a significant decline in early-onset sepsis, the incidence of late-onset sepsis has remained unchanged. Whether late-onset sepsis usually originates from established mucocutaneous GBS colonization of the infant or whether it results from an acute exogenous GBS infection remains controversial. Here we report on twins who both twice developed GBS sepsis in a strikingly parallel fashion, with both instances originating from a single hypervirulent GBS clone. Factored together, the presentation as cervical soft tissue infection in both cases, the synchronicity of the episodes, and the detection of GBS DNA in breast milk all strongly suggest an enteral mode of transmission with a short incubation period.

Original languageEnglish
Pages (from-to)e1388-e1391
JournalPediatrics
Volume133
Issue number5
DOIs
Publication statusPublished - May 2014

Keywords

  • Breast milk
  • Group B streptococcus
  • Late-onset sepsis
  • S agalactiae
  • Sepsis

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